About Us
IgG4-autoimmune diseases (IgG4-AID) are rare but collectively correspond to a significant group of devastating diseases affecting many different organs, e.g. skin, brain, nerves and kidney in patients that often remain unresponsive to current treatments.
IgG4-AID have commonalities indicating a shared underlying immunopathogenesis that make a joint approach to identify new therapeutic targets and test new treatment strategies feasible and necessary.
We hypothesize that genetic risk factors and a dysregulated immune response may lead to an increased susceptibility to produce antibodies targeting self-proteins. These are of a special subclass called IgG4, which are usually harmless but can cause disease in these patients by interfering with normal functions in the body.
We are the first consortium that aims to study IgG4-AID comparatively, including pathogenic IgG4, and the cells, molecules and mechanisms involved in IgG4 autoantibody production, using an explorative multi-omics approaches in combination with state-of-the-art cell and molecular biology methodology.
Consortium Members
